Interações medicamentosas
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir
Gravidade: Moderada
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Entecavir, emtricitabine and tenofovir are all eliminated by the kidney through filtration and active tubular secretion, and cobicistat can raise serum creatinine by inhibiting tubular secretion. Concurrent use may increase concentrations of the renally cleared drugs and the risk of renal adverse events. Entecavir is sometimes combined with tenofovir regimens in hepatitis B coinfection.
O que esta interação significa em palavras simples
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Competition for renal tubular secretion and additive renal burden, which can decrease clearance of each drug.
O que fazer
Monitor serum creatinine, estimated clearance and phosphate regularly. Adjust the entecavir dose if creatinine clearance falls.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Entecavir
- Alogliptin-metformin + Entecavir Moderada
- Canagliflozin-metformin + Entecavir Moderada
- Cidofovir + Entecavir Moderada
- Cyclosporine + Entecavir Moderada
- Dapagliflozin-metformin + Entecavir Moderada
- Empagliflozin-metformin + Entecavir Moderada
Perguntas frequentes
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Entecavir?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir, emtricitabine and tenofovir are all eliminated by the kidney through filtration and active tubular secretion, and cobicistat can raise serum creatinine by inhibiting tubular secretion. Concurrent use may increase concentrations of the renally cleared drugs and the risk of renal adverse events. Entecavir is sometimes combined with tenofovir regimens in hepatitis B coinfection.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated clearance and phosphate regularly. Adjust the entecavir dose if creatinine clearance falls.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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