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Interações medicamentosas

Alogliptin-metformin + Somatropin

Gravidade: Moderada

Alogliptin-metformin and Somatropin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Somatropin can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of antidiabetic drugs. Patients with diabetes may need dose increases after growth hormone is started.

O que esta interação significa em palavras simples

Alogliptin-metformin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Alogliptin-metformin belongs to Endocrine; Somatropin belongs to Endocrine.

Nível de evidência: Moderate

Por que acontece

Growth hormone induces insulin resistance and increases hepatic glucose output, opposing glucose-lowering drugs.

O que fazer

Monitor blood glucose when somatropin is started or its dose changed, and adjust antidiabetic therapy accordingly.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Alogliptin-metformin with Somatropin?

MediHelp rates the interaction as moderate. Alogliptin-metformin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of antidiabetic drugs. Patients with diabetes may need dose increases after growth hormone is started.

How serious is the interaction between Alogliptin-metformin and Somatropin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when somatropin is started or its dose changed, and adjust antidiabetic therapy accordingly.

What other medicines interact with Alogliptin-metformin?

MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.

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