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Interações medicamentosas

Alogliptin-pioglitazone + Somatropin

Gravidade: Moderada

Alogliptin-pioglitazone and Somatropin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Growth hormone reduces insulin sensitivity and can raise blood glucose, opposing the effect of alogliptin and pioglitazone. Patients with diabetes may need higher doses of antidiabetic agents after starting somatropin.

O que esta interação significa em palavras simples

Alogliptin-pioglitazone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Alogliptin-pioglitazone belongs to Endocrine; Somatropin belongs to Endocrine.

Nível de evidência: Moderate

Por que acontece

Growth hormone induces insulin resistance and increases lipolysis and hepatic glucose output.

O que fazer

Monitor blood glucose and HbA1c after starting or changing somatropin and adjust antidiabetic therapy accordingly.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Alogliptin-pioglitazone with Somatropin?

MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and can raise blood glucose, opposing the effect of alogliptin and pioglitazone. Patients with diabetes may need higher doses of antidiabetic agents after starting somatropin.

How serious is the interaction between Alogliptin-pioglitazone and Somatropin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing somatropin and adjust antidiabetic therapy accordingly.

What other medicines interact with Alogliptin-pioglitazone?

MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.

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