Interações medicamentosas
Alogliptin-pioglitazone + Cannabidiol
Gravidade: Moderada
Alogliptin-pioglitazone and Cannabidiol: moderate interaction.
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Resumo
Cannabidiol may inhibit CYP2C8, the main enzyme clearing pioglitazone, and could raise pioglitazone levels. This may increase the risk of fluid retention, edema, weight gain and hypoglycemia.
O que esta interação significa em palavras simples
Alogliptin-pioglitazone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Cannabidiol belongs to Central Nervous System.
Por que acontece
Inhibition of CYP2C8-mediated pioglitazone metabolism.
O que fazer
Monitor for edema, weight gain and glycemic changes when cannabidiol is started, and reduce the pioglitazone dose if adverse effects appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Alogliptin-pioglitazone
Outras interações de Cannabidiol
- Cannabidiol + Phenytoin Grave
- Cannabidiol + Sodium valproate Grave
- Cannabidiol + Tacrolimus Grave
- Abiraterone + Cannabidiol Moderada
- Amiodarone + Cannabidiol Moderada
- Amobarbital + Cannabidiol Moderada
Perguntas frequentes
Can I take Alogliptin-pioglitazone with Cannabidiol?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may inhibit CYP2C8, the main enzyme clearing pioglitazone, and could raise pioglitazone levels. This may increase the risk of fluid retention, edema, weight gain and hypoglycemia.
How serious is the interaction between Alogliptin-pioglitazone and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for edema, weight gain and glycemic changes when cannabidiol is started, and reduce the pioglitazone dose if adverse effects appear.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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