Interações medicamentosas
Amiodarone + Cannabidiol
Gravidade: Moderada
Amiodarone and Cannabidiol: moderate interaction.
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Resumo
Cannabidiol inhibits several CYP enzymes including CYP2C19 and CYP2C8, and amiodarone may raise cannabidiol levels via CYP3A4 inhibition. Both drugs may reach higher concentrations, increasing adverse effects such as sedation, liver enzyme elevation, bradycardia or QT effects.
O que esta interação significa em palavras simples
Amiodarone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Cannabidiol belongs to Central Nervous System.
Por que acontece
Bidirectional inhibition of CYP-mediated metabolism (CYP3A4 for cannabidiol; CYP2C8/2C19 for amiodarone).
O que fazer
Monitor for sedation, liver function and ECG changes, and consider reducing the cannabidiol dose if adverse effects appear. Adjust amiodarone based on heart rate, QTc and clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Outras interações de Cannabidiol
- Cannabidiol + Phenytoin Grave
- Cannabidiol + Sodium valproate Grave
- Cannabidiol + Tacrolimus Grave
- Abiraterone + Cannabidiol Moderada
- Alogliptin-pioglitazone + Cannabidiol Moderada
- Amobarbital + Cannabidiol Moderada
Perguntas frequentes
Can I take Amiodarone with Cannabidiol?
MediHelp rates the interaction as moderate. Amiodarone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits several CYP enzymes including CYP2C19 and CYP2C8, and amiodarone may raise cannabidiol levels via CYP3A4 inhibition. Both drugs may reach higher concentrations, increasing adverse effects such as sedation, liver enzyme elevation, bradycardia or QT effects.
How serious is the interaction between Amiodarone and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, liver function and ECG changes, and consider reducing the cannabidiol dose if adverse effects appear. Adjust amiodarone based on heart rate, QTc and clinical response.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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