Interações medicamentosas
Amantadine + Trihexyphenidyl
Gravidade: Moderada
Amantadine and Trihexyphenidyl: moderate interaction.
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Resumo
Both drugs have anticholinergic activity, so combined use can add to dry mouth, constipation, urinary retention, blurred vision, confusion and hallucinations. Older patients with parkinsonism are particularly susceptible to cognitive adverse effects.
O que esta interação significa em palavras simples
Amantadine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Trihexyphenidyl belongs to Central Nervous System.
Por que acontece
Additive anticholinergic pharmacodynamic effects.
O que fazer
Monitor for confusion, hallucinations and urinary retention, and use the lowest effective doses. Reduce the trihexyphenidyl dose if anticholinergic effects appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amantadine
- Amantadine + Ethanol Grave
- Amantadine + Memantine-donepezil Grave
- Amantadine + Metoclopramide Grave
- Amantadine + Metoclopramide intranasal Grave
- Amantadine + Amifampridine Moderada
- Amantadine + Amisulpride Moderada
Outras interações de Trihexyphenidyl
Perguntas frequentes
Can I take Amantadine with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Amantadine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can add to dry mouth, constipation, urinary retention, blurred vision, confusion and hallucinations. Older patients with parkinsonism are particularly susceptible to cognitive adverse effects.
How serious is the interaction between Amantadine and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, hallucinations and urinary retention, and use the lowest effective doses. Reduce the trihexyphenidyl dose if anticholinergic effects appear.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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