Interações medicamentosas
Oxybutynin + Trihexyphenidyl
Gravidade: Grave
Oxybutynin and Trihexyphenidyl: major interaction.
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Resumo
Both are potent anticholinergics, so together they can cause marked dry mouth, constipation, urinary retention, blurred vision, tachycardia, confusion and hallucinations. Elderly patients are at high risk of delirium and ileus.
O que esta interação significa em palavras simples
Oxybutynin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxybutynin belongs to Genitourinary; Trihexyphenidyl belongs to Central Nervous System.
Por que acontece
Additive muscarinic receptor antagonism.
O que fazer
Avoid the combination where possible, using a non-anticholinergic bladder agent. If used, monitor for delirium, constipation and urinary retention and use the lowest doses.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Oxybutynin
- Bethanechol + Oxybutynin Grave
- Clozapine + Oxybutynin Grave
- Oxybutynin + Potassium chloride Grave
- Oxybutynin + Rivastigmine Grave
- Abobotulinumtoxina + Oxybutynin Moderada
- Aclidinium + Oxybutynin Moderada
Outras interações de Trihexyphenidyl
Perguntas frequentes
Can I take Oxybutynin with Trihexyphenidyl?
MediHelp rates the interaction as major. Oxybutynin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are potent anticholinergics, so together they can cause marked dry mouth, constipation, urinary retention, blurred vision, tachycardia, confusion and hallucinations. Elderly patients are at high risk of delirium and ileus.
How serious is the interaction between Oxybutynin and Trihexyphenidyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using a non-anticholinergic bladder agent. If used, monitor for delirium, constipation and urinary retention and use the lowest doses.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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