Interações medicamentosas
Amifostine + Clonidine
Gravidade: Grave
Amifostine and Clonidine: major interaction.
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Resumo
Amifostine commonly causes hypotension, and antihypertensives such as clonidine can increase its frequency and severity. At chemotherapy doses this can cause significant hemodynamic compromise.
O que esta interação significa em palavras simples
Amifostine and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amifostine belongs to Miscellaneous; Clonidine belongs to Cardiovascular.
Por que acontece
Additive blood pressure lowering through central sympatholytic action and amifostine-induced hypotension.
O que fazer
For chemotherapeutic doses of amifostine, hold clonidine for 24 hours beforehand where safely possible; if it cannot be held, do not give amifostine. Avoid abrupt clonidine withdrawal without a plan for rebound hypertension.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clonidine
- Acebutolol + Clonidine Grave
- Amiodarone + Clonidine Grave
- Amoxapine + Clonidine Grave
- Atenolol-chlorthalidone + Clonidine Grave
- Atenolol + Clonidine Grave
- Betaxolol + Clonidine Grave
Outras interações de Amifostine
Perguntas frequentes
Can I take Amifostine with Clonidine?
MediHelp rates the interaction as major. Amifostine and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amifostine commonly causes hypotension, and antihypertensives such as clonidine can increase its frequency and severity. At chemotherapy doses this can cause significant hemodynamic compromise.
How serious is the interaction between Amifostine and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For chemotherapeutic doses of amifostine, hold clonidine for 24 hours beforehand where safely possible; if it cannot be held, do not give amifostine. Avoid abrupt clonidine withdrawal without a plan for rebound hypertension.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amiodarone, Amoxapine. The full list is on the Clonidine page.
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