Interações medicamentosas
Amifostine + Losartan
Gravidade: Grave
Amifostine and Losartan: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Amifostine commonly causes hypotension, and antihypertensives such as losartan can worsen the fall in blood pressure. At chemotherapeutic doses of amifostine, severe hypotension is a concern.
O que esta interação significa em palavras simples
Amifostine and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amifostine belongs to Miscellaneous; Losartan belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic hypotensive effects of the two drugs.
O que fazer
For chemotherapeutic amifostine doses, withhold losartan for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely and ensure hydration.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amifostine e Losartan, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Losartan
- Aliskiren + Losartan Contraindicada
- Losartan + Sparsentan Contraindicada
- Amiloride + Losartan Grave
- Amlodipine-benazepril + Losartan Grave
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Grave
- Amlodipine-olmesartan-hydrochlorothiazide + Losartan Grave
Outras interações de Amifostine
Perguntas frequentes
Can I take Amifostine with Losartan?
MediHelp rates the interaction as major. Amifostine and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amifostine commonly causes hypotension, and antihypertensives such as losartan can worsen the fall in blood pressure. At chemotherapeutic doses of amifostine, severe hypotension is a concern.
How serious is the interaction between Amifostine and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For chemotherapeutic amifostine doses, withhold losartan for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely and ensure hydration.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amiloride. The full list is on the Losartan page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
