Interações medicamentosas
Amlodipine-benazepril + Losartan
Gravidade: Grave
Amlodipine-benazepril and Losartan: major interaction.
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Resumo
Combining an ACE inhibitor with an angiotensin receptor blocker produces dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and acute kidney injury without clear added cardiovascular benefit.
O que esta interação significa em palavras simples
Amlodipine-benazepril and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two points.
O que fazer
Avoid the combination in most patients and use a single renin-angiotensin agent. If it is used, monitor serum potassium, creatinine and blood pressure closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicada
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicada
- Aldesleukin + Amlodipine-benazepril Grave
- Amifostine + Amlodipine-benazepril Grave
- Amiloride + Amlodipine-benazepril Grave
- Amlodipine-benazepril + Azilsartan Grave
Outras interações de Losartan
- Aliskiren + Losartan Contraindicada
- Losartan + Sparsentan Contraindicada
- Amifostine + Losartan Grave
- Amiloride + Losartan Grave
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Grave
- Amlodipine-olmesartan-hydrochlorothiazide + Losartan Grave
Perguntas frequentes
Can I take Amlodipine-benazepril with Losartan?
MediHelp rates the interaction as major. Amlodipine-benazepril and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an angiotensin receptor blocker produces dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and acute kidney injury without clear added cardiovascular benefit.
How serious is the interaction between Amlodipine-benazepril and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in most patients and use a single renin-angiotensin agent. If it is used, monitor serum potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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