Interações medicamentosas
Amikacin + Cisatracurium
Gravidade: Grave
Amikacin and Cisatracurium: major interaction.
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Resumo
Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers such as cisatracurium. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of apnoea.
O que esta interação significa em palavras simples
Amikacin and Cisatracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Cisatracurium belongs to Musculoskeletal.
Por que acontece
Aminoglycoside reduction of presynaptic acetylcholine release and postsynaptic sensitivity, additive to nondepolarising blockade.
O que fazer
Monitor neuromuscular function with train-of-four and reduce cisatracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cisatracurium
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Cisatracurium?
MediHelp rates the interaction as major. Amikacin and Cisatracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers such as cisatracurium. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of apnoea.
How serious is the interaction between Amikacin and Cisatracurium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce cisatracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen, Capreomycin. The full list is on the Cisatracurium page.
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