Interações medicamentosas
Cisatracurium + Colistin
Gravidade: Grave
Cisatracurium and Colistin: major interaction.
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Resumo
Colistin (polymyxin E) can cause neuromuscular blockade by itself and may potentiate non-depolarizing relaxants such as cisatracurium. Prolonged paralysis and respiratory failure have been described with polymyxins.
O que esta interação significa em palavras simples
Cisatracurium and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisatracurium belongs to Musculoskeletal; Colistin belongs to Anti Bacterial.
Por que acontece
Colistin reduces presynaptic acetylcholine release and stabilizes the postsynaptic membrane, adding to nicotinic receptor blockade by cisatracurium.
O que fazer
Avoid co-administration where possible; if unavoidable, reduce cisatracurium dosing and monitor with train-of-four. Have ventilatory support available, and note that calcium or neostigmine may only partly reverse the effect.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cisatracurium
Outras interações de Colistin
- Colistin + Polymyxin b Contraindicada
- Amikacin + Colistin Grave
- Amphotericin b deoxycholate + Colistin Grave
- Amphotericin b + Colistin Grave
- Atracurium + Colistin Grave
- Bacitracin + Colistin Grave
Perguntas frequentes
Can I take Cisatracurium with Colistin?
MediHelp rates the interaction as major. Cisatracurium and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin (polymyxin E) can cause neuromuscular blockade by itself and may potentiate non-depolarizing relaxants such as cisatracurium. Prolonged paralysis and respiratory failure have been described with polymyxins.
How serious is the interaction between Cisatracurium and Colistin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration where possible; if unavoidable, reduce cisatracurium dosing and monitor with train-of-four. Have ventilatory support available, and note that calcium or neostigmine may only partly reverse the effect.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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