Interações medicamentosas
Amitriptyline + Atropine
Gravidade: Moderada
Amitriptyline and Atropine: moderate interaction.
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Resumo
Both drugs have antimuscarinic activity, so combined use can produce additive effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients and those with glaucoma or prostatic hyperplasia are at particular risk.
O que esta interação significa em palavras simples
Amitriptyline and Atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Atropine belongs to Miscellaneous.
Por que acontece
Additive blockade of muscarinic acetylcholine receptors.
O que fazer
Monitor for anticholinergic toxicity such as urinary retention, ileus, confusion and tachycardia. Use the lowest effective doses or choose a less anticholinergic alternative in high-risk patients.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Atropine
- Atropine + Eluxadoline Grave
- Atropine + Henbane Grave
- Atropine + Pramlintide Grave
- Abobotulinumtoxina + Atropine Moderada
- Aclidinium + Atropine Moderada
- Amantadine + Atropine Moderada
Perguntas frequentes
Can I take Amitriptyline with Atropine?
MediHelp rates the interaction as moderate. Amitriptyline and Atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can produce additive effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients and those with glaucoma or prostatic hyperplasia are at particular risk.
How serious is the interaction between Amitriptyline and Atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, ileus, confusion and tachycardia. Use the lowest effective doses or choose a less anticholinergic alternative in high-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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