Interações medicamentosas
Amitriptyline + Procarbazine
Gravidade: Contraindicada
Amitriptyline and Procarbazine: contraindicated interaction.
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Resumo
Amitriptyline blocks reuptake of serotonin and noradrenaline while procarbazine stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.
O que esta interação significa em palavras simples
Amitriptyline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Procarbazine belongs to Oncology.
Por que acontece
MAO inhibition combined with monoamine reuptake inhibition causes excess synaptic serotonin and noradrenaline
O que fazer
Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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- Additional notes
- Evidence detail
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Safinamide Contraindicada
- Amitriptyline + Selegiline Contraindicada
Outras interações de Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicada
- Amoxapine + Procarbazine Contraindicada
- Atomoxetine + Procarbazine Contraindicada
- Bcg vaccine live + Procarbazine Contraindicada
- Brimonidine + Procarbazine Contraindicada
- Buspirone + Procarbazine Contraindicada
Perguntas frequentes
Can I take Amitriptyline with Procarbazine?
MediHelp rates the interaction as contraindicated. Amitriptyline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amitriptyline blocks reuptake of serotonin and noradrenaline while procarbazine stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.
How serious is the interaction between Amitriptyline and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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