Interações medicamentosas
Amitriptyline + Dicyclomine
Gravidade: Moderada
Amitriptyline and Dicyclomine: moderate interaction.
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Resumo
Both drugs have antimuscarinic activity, so combined use increases the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Older adults and those with glaucoma, prostatic enlargement or ileus are at particular risk.
O que esta interação significa em palavras simples
Amitriptyline and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Por que acontece
Additive muscarinic receptor blockade.
O que fazer
Monitor for anticholinergic effects, and consider a lower dose or an alternative with less antimuscarinic activity in older patients. Avoid in patients with urinary retention, narrow-angle glaucoma or ileus.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dicyclomine
- Clozapine + Dicyclomine Grave
- Dicyclomine + Henbane Grave
- Dicyclomine + Imipramine Grave
- Dicyclomine + Pramlintide Grave
- Abobotulinumtoxina + Dicyclomine Moderada
- Aclidinium + Dicyclomine Moderada
Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Perguntas frequentes
Can I take Amitriptyline with Dicyclomine?
MediHelp rates the interaction as moderate. Amitriptyline and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use increases the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Older adults and those with glaucoma, prostatic enlargement or ileus are at particular risk.
How serious is the interaction between Amitriptyline and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, and consider a lower dose or an alternative with less antimuscarinic activity in older patients. Avoid in patients with urinary retention, narrow-angle glaucoma or ileus.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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