Interações medicamentosas
Amitriptyline + Entrectinib
Gravidade: Grave
Amitriptyline and Entrectinib: major interaction.
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Resumo
Both drugs can prolong the QTc interval, so combined use increases the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or heart disease.
O que esta interação significa em palavras simples
Amitriptyline and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Entrectinib belongs to Oncology.
Por que acontece
Additive blockade of cardiac repolarizing potassium channels leading to QTc prolongation.
O que fazer
Obtain a baseline ECG and monitor it periodically, keeping potassium and magnesium normal. Consider an alternative antidepressant if QTc lengthens substantially.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Entrectinib
Perguntas frequentes
Can I take Amitriptyline with Entrectinib?
MediHelp rates the interaction as major. Amitriptyline and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so combined use increases the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or heart disease.
How serious is the interaction between Amitriptyline and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, keeping potassium and magnesium normal. Consider an alternative antidepressant if QTc lengthens substantially.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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