Interações medicamentosas
Amitriptyline + Pasireotide
Gravidade: Grave
Amitriptyline and Pasireotide: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both drugs can prolong the QT interval, and pasireotide may also cause bradycardia, which increases the risk of torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia or underlying heart disease.
O que esta interação significa em palavras simples
Amitriptyline and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Por que acontece
Additive prolongation of cardiac repolarization, with pasireotide-related bradycardia increasing the arrhythmic risk.
O que fazer
Obtain a baseline ECG and monitor it during treatment, and correct potassium and magnesium abnormalities before and during therapy. Consider an alternative to amitriptyline if QTc becomes prolonged.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amitriptyline e Pasireotide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Pasireotide
- Dronedarone + Pasireotide Contraindicada
- Pasireotide + Pimozide Contraindicada
- Amiodarone + Pasireotide Grave
- Amisulpride + Pasireotide Grave
- Anagrelide + Pasireotide Grave
- Asenapine + Pasireotide Grave
Perguntas frequentes
Can I take Amitriptyline with Pasireotide?
MediHelp rates the interaction as major. Amitriptyline and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and pasireotide may also cause bradycardia, which increases the risk of torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia or underlying heart disease.
How serious is the interaction between Amitriptyline and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment, and correct potassium and magnesium abnormalities before and during therapy. Consider an alternative to amitriptyline if QTc becomes prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
