Interações medicamentosas
Amitriptyline + Primidone
Gravidade: Grave
Amitriptyline and Primidone: major interaction.
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Resumo
Primidone is metabolized to phenobarbital, which induces hepatic enzymes and may reduce amitriptyline levels. Additive sedation is also likely, and tricyclics may lower the seizure threshold.
O que esta interação significa em palavras simples
Amitriptyline and Primidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Primidone belongs to Central Nervous System.
Por que acontece
Enzyme induction (CYP3A4 and CYP2C19) by primidone and its phenobarbital metabolite, plus additive CNS depression.
O que fazer
Monitor for loss of antidepressant effect, sedation, and seizure control, and adjust amitriptyline dose by response or levels. Reassess dosing if primidone is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Primidone
- Lorlatinib + Primidone Contraindicada
- Lurasidone + Primidone Contraindicada
- Primidone + Ranolazine Contraindicada
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicada
- Primidone + Voriconazole Contraindicada
- Abiraterone + Primidone Grave
Perguntas frequentes
Can I take Amitriptyline with Primidone?
MediHelp rates the interaction as major. Amitriptyline and Primidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Primidone is metabolized to phenobarbital, which induces hepatic enzymes and may reduce amitriptyline levels. Additive sedation is also likely, and tricyclics may lower the seizure threshold.
How serious is the interaction between Amitriptyline and Primidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant effect, sedation, and seizure control, and adjust amitriptyline dose by response or levels. Reassess dosing if primidone is stopped.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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