Interações medicamentosas
Brimonidine + Procarbazine
Gravidade: Contraindicada
Brimonidine and Procarbazine: contraindicated interaction.
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Resumo
Brimonidine labelling forbids use with MAO inhibitors, and procarbazine is a cytotoxic drug with weak MAO-inhibiting activity. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
O que esta interação significa em palavras simples
Brimonidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Procarbazine belongs to Oncology.
Por que acontece
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
O que fazer
Avoid brimonidine in patients taking procarbazine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Brimonidine
- Brimonidine + Isocarboxazid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Brimonidine + Phenelzine Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Brimonidine + Selegiline Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Outras interações de Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amoxapine + Procarbazine Contraindicada
- Atomoxetine + Procarbazine Contraindicada
- Bcg vaccine live + Procarbazine Contraindicada
- Buspirone + Procarbazine Contraindicada
Perguntas frequentes
Can I take Brimonidine with Procarbazine?
MediHelp rates the interaction as contraindicated. Brimonidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and procarbazine is a cytotoxic drug with weak MAO-inhibiting activity. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking procarbazine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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