Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Dofetilide
Gravidade: Contraindicada
Amlodipine-hydrochlorothiazide-valsartan and Dofetilide: contraindicated interaction.
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Resumo
Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Por que acontece
Thiazide-related reduction in renal elimination of dofetilide, with electrolyte disturbances adding to QT prolongation.
O que fazer
Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Dofetilide
- Amiodarone + Dofetilide Contraindicada
- Amisulpride + Dofetilide Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Captopril-hydrochlorothiazide + Dofetilide Contraindicada
- Chloroquine + Dofetilide Contraindicada
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dofetilide?
MediHelp rates the interaction as contraindicated. Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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