Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Dofetilide
Severity: Contraindicated
Amlodipine-hydrochlorothiazide-valsartan and Dofetilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Why it happens
Thiazide-related reduction in renal elimination of dofetilide, with electrolyte disturbances adding to QT prolongation.
What to do
Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Chloroquine + Dofetilide Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dofetilide?
MediHelp rates the interaction as contraindicated. Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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