Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Enalapril
Gravidade: Grave
Amlodipine-hydrochlorothiazide-valsartan and Enalapril: major interaction.
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Resumo
Enalapril added to valsartan creates dual renin-angiotensin system blockade. The result is a higher incidence of hypotension, hyperkalemia and renal impairment without compensating benefit.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Enalapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Enalapril belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system by an ACE inhibitor together with an angiotensin receptor blocker.
O que fazer
Avoid the combination and use one renin-angiotensin agent. If co-prescribed, monitor potassium, creatinine and blood pressure frequently.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Enalapril
- Aliskiren + Enalapril Contraindicada
- Enalapril + Protein a column Contraindicada
- Enalapril + Sacubitril / valsartan Contraindicada
- Enalapril + Sacubitril-valsartan Contraindicada
- Amifostine + Enalapril Grave
- Amiloride + Enalapril Grave
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Enalapril?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Enalapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enalapril added to valsartan creates dual renin-angiotensin system blockade. The result is a higher incidence of hypotension, hyperkalemia and renal impairment without compensating benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Enalapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use one renin-angiotensin agent. If co-prescribed, monitor potassium, creatinine and blood pressure frequently.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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