Interações medicamentosas
Amlodipine-olmesartan-hydrochlorothiazide + Captopril
Gravidade: Grave
Amlodipine-olmesartan-hydrochlorothiazide and Captopril: major interaction.
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Resumo
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.
O que esta interação significa em palavras simples
Amlodipine-olmesartan-hydrochlorothiazide and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Captopril belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites, which reduces glomerular filtration pressure and aldosterone-mediated potassium excretion.
O que fazer
Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicada
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Grave
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Grave
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Grave
Outras interações de Captopril
- Aliskiren + Captopril Contraindicada
- Captopril + Sacubitril / valsartan Contraindicada
- Captopril + Sacubitril-valsartan Contraindicada
- Amifostine + Captopril Grave
- Amiloride + Captopril Grave
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Grave
Perguntas frequentes
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Captopril?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Captopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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