Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Captopril
Gravidade: Grave
Amlodipine-hydrochlorothiazide-valsartan and Captopril: major interaction.
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Resumo
Combining captopril with valsartan results in dual renin-angiotensin system blockade. This increases the likelihood of hypotension, hyperkalemia and deterioration of renal function, with no clear added outcome benefit.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Captopril belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system by an ACE inhibitor and an angiotensin receptor blocker.
O que fazer
Avoid concurrent use and choose one renin-angiotensin blocker. If both are given, check potassium and creatinine frequently and monitor blood pressure.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Captopril
- Aliskiren + Captopril Contraindicada
- Captopril + Sacubitril / valsartan Contraindicada
- Captopril + Sacubitril-valsartan Contraindicada
- Amifostine + Captopril Grave
- Amiloride + Captopril Grave
- Amlodipine-olmesartan-hydrochlorothiazide + Captopril Grave
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Captopril?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining captopril with valsartan results in dual renin-angiotensin system blockade. This increases the likelihood of hypotension, hyperkalemia and deterioration of renal function, with no clear added outcome benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Captopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose one renin-angiotensin blocker. If both are given, check potassium and creatinine frequently and monitor blood pressure.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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