Interações medicamentosas
Amlodipine-perindopril + Sacubitril / valsartan
Gravidade: Contraindicada
Amlodipine-perindopril and Sacubitril / valsartan: contraindicated interaction.
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Resumo
Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
O que esta interação significa em palavras simples
Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive RAAS blockade, and neprilysin inhibition combined with ACE inhibition both impair bradykinin breakdown, raising angioedema risk.
O que fazer
Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicada
- Amlodipine-perindopril + Protein a column Contraindicada
- Amifostine + Amlodipine-perindopril Grave
- Amiloride + Amlodipine-perindopril Grave
- Amlodipine-perindopril + Azilsartan Grave
- Amlodipine-perindopril + Candesartan Grave
Perguntas frequentes
Can I take Amlodipine-perindopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
How serious is the interaction between Amlodipine-perindopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Amifostine. The full list is on the Amlodipine-perindopril page.
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