Interações medicamentosas
Amphetamine polistirex + Safinamide
Gravidade: Contraindicada
Amphetamine polistirex and Safinamide: contraindicated interaction.
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Resumo
Amphetamines with an MAO inhibitor risk hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates concomitant use with sympathomimetic stimulants.
O que esta interação significa em palavras simples
Amphetamine polistirex and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Amphetamine releases monoamines and inhibits their reuptake while MAO-B inhibition lessens their metabolism, causing additive effects.
O que fazer
Do not co-administer; use a non-stimulant treatment when safinamide is needed. Observe a washout interval after stopping either drug.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Safinamide
- Amitriptyline + Safinamide Contraindicada
- Amoxapine + Safinamide Contraindicada
- Clomipramine + Safinamide Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Desipramine + Safinamide Contraindicada
- Desvenlafaxine + Safinamide Contraindicada
Perguntas frequentes
Can I take Amphetamine polistirex with Safinamide?
MediHelp rates the interaction as contraindicated. Amphetamine polistirex and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines with an MAO inhibitor risk hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates concomitant use with sympathomimetic stimulants.
How serious is the interaction between Amphetamine polistirex and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-stimulant treatment when safinamide is needed. Observe a washout interval after stopping either drug.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Clomipramine. The full list is on the Safinamide page.
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