Interações medicamentosas
Amphotericin b + Tobramycin
Gravidade: Grave
Amphotericin b and Tobramycin: major interaction.
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Resumo
Both drugs are nephrotoxic, and tobramycin is also ototoxic and vestibulotoxic. Combined use raises the risk of acute kidney injury, which in turn increases aminoglycoside accumulation and the risk of permanent hearing or balance damage.
O que esta interação significa em palavras simples
Amphotericin b and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Tobramycin belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxicity from renal tubular injury, with reduced aminoglycoside clearance amplifying ototoxicity.
O que fazer
Avoid the combination if an alternative exists. If it is necessary, monitor serum creatinine, electrolytes and tobramycin levels frequently, ensure hydration, and consider a lipid-based amphotericin formulation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amphotericin b
- Amphotericin b + Cidofovir Contraindicada
- Adefovir + Amphotericin b Grave
- Amikacin + Amphotericin b Grave
- Amphotericin b + Arsenic trioxide Grave
- Amphotericin b + Capreomycin Grave
- Amphotericin b + Cephaloridine Grave
Outras interações de Tobramycin
- Cidofovir + Tobramycin Contraindicada
- Adefovir + Tobramycin Grave
- Amikacin + Tobramycin Grave
- Amphotericin b deoxycholate + Tobramycin Grave
- Atracurium + Tobramycin Grave
- Bacitracin + Tobramycin Grave
Perguntas frequentes
Can I take Amphotericin b with Tobramycin?
MediHelp rates the interaction as major. Amphotericin b and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and tobramycin is also ototoxic and vestibulotoxic. Combined use raises the risk of acute kidney injury, which in turn increases aminoglycoside accumulation and the risk of permanent hearing or balance damage.
How serious is the interaction between Amphotericin b and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor serum creatinine, electrolytes and tobramycin levels frequently, ensure hydration, and consider a lipid-based amphotericin formulation.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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