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Interações medicamentosas

Amphotericin b + Arsenic trioxide

Gravidade: Grave

Amphotericin b and Arsenic trioxide: major interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Amphotericin B can cause hypokalemia and hypomagnesemia, which raise the risk of QT prolongation and torsade de pointes with arsenic trioxide.

O que esta interação significa em palavras simples

Amphotericin b and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amphotericin b belongs to Anti Fungals; Arsenic trioxide belongs to Oncology.

Nível de evidência: Moderate

Por que acontece

Amphotericin-induced electrolyte loss adds to the QT-prolonging effect of arsenic trioxide.

O que fazer

Correct potassium and magnesium before and during therapy and monitor ECG and electrolytes frequently; avoid the combination if alternatives exist.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Amphotericin b with Arsenic trioxide?

MediHelp rates the interaction as major. Amphotericin b and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B can cause hypokalemia and hypomagnesemia, which raise the risk of QT prolongation and torsade de pointes with arsenic trioxide.

How serious is the interaction between Amphotericin b and Arsenic trioxide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy and monitor ECG and electrolytes frequently; avoid the combination if alternatives exist.

What other medicines interact with Arsenic trioxide?

MediHelp also lists interactions of Arsenic trioxide with, for example, Amiodarone, Amisulpride, Clomipramine. The full list is on the Arsenic trioxide page.

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