Interações medicamentosas
Ampicillin + Chloramphenicol
Gravidade: Moderada
Ampicillin and Chloramphenicol: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Chloramphenicol may antagonize the bactericidal effect of ampicillin, and worse outcomes have been suggested in some serious infections such as meningitis. The data are mostly in vitro or observational.
O que esta interação significa em palavras simples
Ampicillin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Por que acontece
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis and growth reduces penicillin killing.
O que fazer
Avoid the combination in meningitis, endocarditis and other infections requiring bactericidal therapy; choose one active agent based on susceptibility.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ampicillin
- Allopurinol + Ampicillin Moderada
- Ampicillin + Bcg vaccine live Moderada
- Ampicillin + Chloroquine Moderada
- Ampicillin + Cholera vaccine Moderada
- Ampicillin + Demeclocycline Moderada
- Ampicillin + Eravacycline Moderada
Outras interações de Chloramphenicol
Perguntas frequentes
Can I take Ampicillin with Chloramphenicol?
MediHelp rates the interaction as moderate. Ampicillin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may antagonize the bactericidal effect of ampicillin, and worse outcomes have been suggested in some serious infections such as meningitis. The data are mostly in vitro or observational.
How serious is the interaction between Ampicillin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in meningitis, endocarditis and other infections requiring bactericidal therapy; choose one active agent based on susceptibility.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloroquine. The full list is on the Ampicillin page.
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