Interações medicamentosas
Bcg vaccine live + Chloramphenicol
Gravidade: Grave
Bcg vaccine live and Chloramphenicol: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Chloramphenicol is active against many bacteria and may reduce the replication of the live attenuated bacteria in the vaccine. This can lead to a weaker immune response and reduced protection.
O que esta interação significa em palavras simples
Bcg vaccine live and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Antibacterial activity of chloramphenicol may inhibit the live attenuated bacterial vaccine strain, reducing immunogenicity.
O que fazer
Defer the live BCG vaccination until the chloramphenicol course is finished, allowing an adequate washout interval. Revaccinate if the vaccine was given during antibiotic therapy.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chloramphenicol
Perguntas frequentes
Can I take Bcg vaccine live with Chloramphenicol?
MediHelp rates the interaction as major. Bcg vaccine live and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol is active against many bacteria and may reduce the replication of the live attenuated bacteria in the vaccine. This can lead to a weaker immune response and reduced protection.
How serious is the interaction between Bcg vaccine live and Chloramphenicol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer the live BCG vaccination until the chloramphenicol course is finished, allowing an adequate washout interval. Revaccinate if the vaccine was given during antibiotic therapy.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Benzhydrocodone / acetaminophen. The full list is on the Chloramphenicol page.
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