Interações medicamentosas
Anagrelide + Cilostazol
Gravidade: Grave
Anagrelide and Cilostazol: major interaction.
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Resumo
Both drugs are PDE3 inhibitors, so combining them may amplify cardiovascular effects such as tachycardia, palpitations, fluid retention and hypotension. Anagrelide labeling advises caution with other PDE3 inhibitors, and bleeding risk may also be additive.
O que esta interação significa em palavras simples
Anagrelide and Cilostazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Cilostazol belongs to Cardiovascular.
Por que acontece
Additive PDE3 inhibition producing enhanced inotropic, chronotropic, vasodilatory and antiplatelet effects.
O que fazer
Avoid the combination where possible; if used, monitor heart rate, blood pressure, signs of heart failure and bleeding closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cilostazol
Outras interações de Anagrelide
- Anagrelide + Panobinostat Contraindicada
- Anagrelide + Pimozide Contraindicada
- Anagrelide + Thioridazine Contraindicada
- Anagrelide + Vandetanib Contraindicada
- Abrocitinib + Anagrelide Grave
- Alfuzosin + Anagrelide Grave
Perguntas frequentes
Can I take Anagrelide with Cilostazol?
MediHelp rates the interaction as major. Anagrelide and Cilostazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are PDE3 inhibitors, so combining them may amplify cardiovascular effects such as tachycardia, palpitations, fluid retention and hypotension. Anagrelide labeling advises caution with other PDE3 inhibitors, and bleeding risk may also be additive.
How serious is the interaction between Anagrelide and Cilostazol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor heart rate, blood pressure, signs of heart failure and bleeding closely.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Betrixaban, Cobicistat. The full list is on the Cilostazol page.
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