Interações medicamentosas
Antithrombin iii + Piperacillin-tazobactam
Gravidade: Moderada
Antithrombin iii and Piperacillin-tazobactam: moderate interaction.
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Resumo
Piperacillin can impair platelet aggregation and may increase bleeding tendency. Antithrombin III potentiates heparin-type anticoagulation, so the bleeding risk may be additive. Clinical data are limited.
O que esta interação significa em palavras simples
Antithrombin iii and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive hemostatic impairment from penicillin-related platelet dysfunction and enhanced antithrombin-mediated anticoagulation.
O que fazer
Monitor for bleeding and coagulation tests, especially if heparin is co-administered. Reduce anticoagulant dose if bleeding or excessive anticoagulation occurs.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Piperacillin-tazobactam
Perguntas frequentes
Can I take Antithrombin iii with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Antithrombin iii and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet aggregation and may increase bleeding tendency. Antithrombin III potentiates heparin-type anticoagulation, so the bleeding risk may be additive. Clinical data are limited.
How serious is the interaction between Antithrombin iii and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation tests, especially if heparin is co-administered. Reduce anticoagulant dose if bleeding or excessive anticoagulation occurs.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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