Interações medicamentosas
Piperacillin-tazobactam + Vancomycin
Gravidade: Grave
Piperacillin-tazobactam and Vancomycin: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Concurrent use is associated with a higher incidence of acute kidney injury than vancomycin with other beta-lactams. Some of the rise in serum creatinine may reflect reduced tubular secretion, but true kidney injury has been reported. Risk is higher with high vancomycin exposure, critical illness, or other nephrotoxins.
O que esta interação significa em palavras simples
Piperacillin-tazobactam and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piperacillin-tazobactam belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
Por que acontece
Additive or synergistic nephrotoxicity, with possible effects on tubular creatinine secretion; mechanism not fully defined.
O que fazer
Monitor serum creatinine and urine output frequently and keep vancomycin levels within target. Consider an alternative beta-lactam if renal function declines.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Piperacillin-tazobactam
Outras interações de Vancomycin
- Amikacin + Vancomycin Grave
- Bacitracin + Vancomycin Grave
- Capreomycin + Vancomycin Grave
- Cephaloridine + Vancomycin Grave
- Cidofovir + Vancomycin Grave
- Cisplatin + Vancomycin Grave
Perguntas frequentes
Can I take Piperacillin-tazobactam with Vancomycin?
MediHelp rates the interaction as major. Piperacillin-tazobactam and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use is associated with a higher incidence of acute kidney injury than vancomycin with other beta-lactams. Some of the rise in serum creatinine may reflect reduced tubular secretion, but true kidney injury has been reported. Risk is higher with high vancomycin exposure, critical illness, or other nephrotoxins.
How serious is the interaction between Piperacillin-tazobactam and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output frequently and keep vancomycin levels within target. Consider an alternative beta-lactam if renal function declines.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Amikacin, Antithrombin alfa, Antithrombin iii. The full list is on the Piperacillin-tazobactam page.
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