Interações medicamentosas
Apixaban + Ketorolac
Gravidade: Contraindicada
Apixaban and Ketorolac: contraindicated interaction.
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Resumo
Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
O que esta interação significa em palavras simples
Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Por que acontece
Additive hemostatic impairment: NSAID antiplatelet effect and mucosal injury combined with factor Xa inhibition.
O que fazer
Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ketorolac
- Aceclofenac + Ketorolac Contraindicada
- Acemetacin + Ketorolac Contraindicada
- Acetylsalicylic acid + Ketorolac Contraindicada
- Argatroban + Ketorolac Contraindicada
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicada
- Aspirin rectal + Ketorolac Contraindicada
Outras interações de Apixaban
- Apixaban + Dabigatran Contraindicada
- Apixaban + Defibrotide Contraindicada
- Apixaban + Edoxaban Contraindicada
- Apixaban + Mifepristone Contraindicada
- Abciximab + Apixaban Grave
- Acalabrutinib + Apixaban Grave
Perguntas frequentes
Can I take Apixaban with Ketorolac?
MediHelp rates the interaction as contraindicated. Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
How serious is the interaction between Apixaban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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