Interações medicamentosas
Apixaban + Edoxaban
Gravidade: Contraindicada
Apixaban and Edoxaban: contraindicated interaction.
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Resumo
Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
O que esta interação significa em palavras simples
Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Por que acontece
Duplicate pharmacodynamic effect through factor Xa inhibition.
O que fazer
Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Apixaban
- Apixaban + Dabigatran Contraindicada
- Apixaban + Defibrotide Contraindicada
- Apixaban + Ketorolac Contraindicada
- Apixaban + Mifepristone Contraindicada
- Abciximab + Apixaban Grave
- Acalabrutinib + Apixaban Grave
Outras interações de Edoxaban
- Defibrotide + Edoxaban Contraindicada
- Edoxaban + Ketorolac Contraindicada
- Abciximab + Edoxaban Grave
- Acetylsalicylic acid + Edoxaban Grave
- Argatroban + Edoxaban Grave
- Aspirin rectal + Edoxaban Grave
Perguntas frequentes
Can I take Apixaban with Edoxaban?
MediHelp rates the interaction as contraindicated. Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
How serious is the interaction between Apixaban and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Ketorolac. The full list is on the Apixaban page.
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