Interações medicamentosas
Aprepitant + Cobimetinib
Gravidade: Grave
Aprepitant and Cobimetinib: major interaction.
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Resumo
Aprepitant is a moderate CYP3A4 inhibitor and can raise cobimetinib concentrations. This increases the risk of cobimetinib toxicity such as rash, diarrhea, hemorrhage, liver injury and retinopathy.
O que esta interação significa em palavras simples
Aprepitant and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Cobimetinib belongs to Oncology.
Por que acontece
Aprepitant inhibits CYP3A4, reducing the metabolism of cobimetinib, a CYP3A substrate.
O que fazer
Avoid the combination and use an alternative antiemetic. If short-term use is unavoidable, reduce cobimetinib to 20 mg daily as labeled and monitor closely for toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Aprepitant
- Aprepitant + Lomitapide Contraindicada
- Aprepitant + Pimozide Contraindicada
- Aprepitant + Avapritinib Grave
- Aprepitant + Bosutinib Grave
- Aprepitant + Carbamazepine Grave
- Aprepitant + Cobicistat Grave
Outras interações de Cobimetinib
- Cobimetinib + Efavirenz Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Amobarbital + Cobimetinib Grave
- Apalutamide + Cobimetinib Grave
- Bosentan + Cobimetinib Grave
- Carbamazepine + Cobimetinib Grave
Perguntas frequentes
Can I take Aprepitant with Cobimetinib?
MediHelp rates the interaction as major. Aprepitant and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant is a moderate CYP3A4 inhibitor and can raise cobimetinib concentrations. This increases the risk of cobimetinib toxicity such as rash, diarrhea, hemorrhage, liver injury and retinopathy.
How serious is the interaction between Aprepitant and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiemetic. If short-term use is unavoidable, reduce cobimetinib to 20 mg daily as labeled and monitor closely for toxicity.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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