Interações medicamentosas
Cobimetinib + Posaconazole
Gravidade: Contraindicada
Cobimetinib and Posaconazole: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Posaconazole markedly raises cobimetinib exposure, increasing risks of hemorrhage, rhabdomyolysis, retinopathy, diarrhea and skin toxicity.
O que esta interação significa em palavras simples
Cobimetinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobimetinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Por que acontece
Strong CYP3A4 inhibition reduces cobimetinib clearance.
O que fazer
Avoid; use an antifungal or other therapy without strong CYP3A4 inhibition. If unavoidable, follow labeling for substantial cobimetinib dose reduction and monitor for toxicity.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Cobimetinib e Posaconazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Conivaptan + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dihydroergotamine + Posaconazole Contraindicada
- Dronedarone + Posaconazole Contraindicada
Outras interações de Cobimetinib
- Cobimetinib + Efavirenz Contraindicada
- Amobarbital + Cobimetinib Grave
- Apalutamide + Cobimetinib Grave
- Aprepitant + Cobimetinib Grave
- Bosentan + Cobimetinib Grave
- Carbamazepine + Cobimetinib Grave
Perguntas frequentes
Can I take Cobimetinib with Posaconazole?
MediHelp rates the interaction as contraindicated. Cobimetinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole markedly raises cobimetinib exposure, increasing risks of hemorrhage, rhabdomyolysis, retinopathy, diarrhea and skin toxicity.
How serious is the interaction between Cobimetinib and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an antifungal or other therapy without strong CYP3A4 inhibition. If unavoidable, follow labeling for substantial cobimetinib dose reduction and monitor for toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Conivaptan. The full list is on the Posaconazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
