Interações medicamentosas
Argatroban + Deferasirox
Gravidade: Grave
Argatroban and Deferasirox: major interaction.
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Resumo
Deferasirox can cause gastrointestinal ulceration and hemorrhage, and argatroban is a direct thrombin inhibitor that impairs clotting. Together the risk of serious GI bleeding is increased.
O que esta interação significa em palavras simples
Argatroban and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Por que acontece
Additive bleeding risk: mucosal injury from deferasirox plus anticoagulation from argatroban.
O que fazer
Monitor for signs of GI bleeding and hemoglobin, and monitor aPTT per argatroban protocol. Consider gastroprotection and avoid the combination in patients with prior GI ulcer or bleeding.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Deferasirox
Outras interações de Argatroban
- Argatroban + Defibrotide Contraindicada
- Argatroban + Ketorolac Contraindicada
- Argatroban + Mifepristone Contraindicada
- Abciximab + Argatroban Grave
- Acalabrutinib + Argatroban Grave
- Acetylsalicylic acid + Argatroban Grave
Perguntas frequentes
Can I take Argatroban with Deferasirox?
MediHelp rates the interaction as major. Argatroban and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause gastrointestinal ulceration and hemorrhage, and argatroban is a direct thrombin inhibitor that impairs clotting. Together the risk of serious GI bleeding is increased.
How serious is the interaction between Argatroban and Deferasirox?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and hemoglobin, and monitor aPTT per argatroban protocol. Consider gastroprotection and avoid the combination in patients with prior GI ulcer or bleeding.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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