Interações medicamentosas
Aspirin / citric acid / sodium bicarbonate + Deferasirox
Gravidade: Grave
Aspirin / citric acid / sodium bicarbonate and Deferasirox: major interaction.
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Resumo
The aspirin component adds gastric mucosal injury and antiplatelet effect to the ulcer and hemorrhage risk already associated with deferasirox. Bleeding risk is therefore increased.
O que esta interação significa em palavras simples
Aspirin / citric acid / sodium bicarbonate and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive GI mucosal injury plus aspirin-induced platelet inhibition.
O que fazer
Avoid the combination if possible and use a non-NSAID analgesic instead. If aspirin is needed, add gastroprotection and monitor for GI bleeding.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Deferasirox
Perguntas frequentes
Can I take Aspirin / citric acid / sodium bicarbonate with Deferasirox?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The aspirin component adds gastric mucosal injury and antiplatelet effect to the ulcer and hemorrhage risk already associated with deferasirox. Bleeding risk is therefore increased.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Deferasirox?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-NSAID analgesic instead. If aspirin is needed, add gastroprotection and monitor for GI bleeding.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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