Interações medicamentosas
Aripiprazole + Carbamazepine
Gravidade: Grave
Aripiprazole and Carbamazepine: major interaction.
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Resumo
Carbamazepine markedly lowers aripiprazole concentrations by enzyme induction, which may cause relapse of psychiatric symptoms.
O que esta interação significa em palavras simples
Aripiprazole and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Carbamazepine belongs to Central Nervous System.
Por que acontece
Induction of CYP3A4 by carbamazepine increases aripiprazole clearance.
O que fazer
Double the aripiprazole dose when carbamazepine is added and monitor response. Reduce it back when carbamazepine is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Aripiprazole
- Aripiprazole + Pimozide Contraindicada
- Aripiprazole + Thioridazine Contraindicada
- Amisulpride + Aripiprazole Grave
- Aripiprazole + Arsenic trioxide Grave
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Grave
- Aripiprazole + Cisapride Grave
Outras interações de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicada
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
Perguntas frequentes
Can I take Aripiprazole with Carbamazepine?
MediHelp rates the interaction as major. Aripiprazole and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine markedly lowers aripiprazole concentrations by enzyme induction, which may cause relapse of psychiatric symptoms.
How serious is the interaction between Aripiprazole and Carbamazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Double the aripiprazole dose when carbamazepine is added and monitor response. Reduce it back when carbamazepine is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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