Interações medicamentosas
Artemether / lumefantrine + Carbamazepine
Gravidade: Contraindicada
Artemether / lumefantrine and Carbamazepine: contraindicated interaction.
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Resumo
Carbamazepine, a strong CYP3A4 inducer, can markedly lower artemether and lumefantrine concentrations. This may cause antimalarial treatment failure. Labeling contraindicates use of strong inducers.
O que esta interação significa em palavras simples
Artemether / lumefantrine and Carbamazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Carbamazepine induces CYP3A4, accelerating metabolism of artemether and lumefantrine.
O que fazer
Avoid the combination and choose an alternative antimalarial not affected by enzyme induction. Seek specialist advice for malaria treatment.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Carbamazepine
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
- Carbamazepine + Ensitrelvir Contraindicada
Perguntas frequentes
Can I take Artemether / lumefantrine with Carbamazepine?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Carbamazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine, a strong CYP3A4 inducer, can markedly lower artemether and lumefantrine concentrations. This may cause antimalarial treatment failure. Labeling contraindicates use of strong inducers.
How serious is the interaction between Artemether / lumefantrine and Carbamazepine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antimalarial not affected by enzyme induction. Seek specialist advice for malaria treatment.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Cabotegravir, Delamanid, Dienogest / estradiol valerate. The full list is on the Carbamazepine page.
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