Interações medicamentosas
Artemether / lumefantrine + Dronedarone
Gravidade: Contraindicada
Artemether / lumefantrine and Dronedarone: contraindicated interaction.
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Resumo
Both components prolong the QT interval, and the combination with dronedarone increases torsades risk. Artemether is also a CYP3A4 substrate with possible effects on dronedarone exposure, though QT additivity is the main concern.
O que esta interação significa em palavras simples
Artemether / lumefantrine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive QT prolongation, with possible CYP3A4-mediated pharmacokinetic effects.
O que fazer
Avoid the combination; use an antimalarial without QT liability or withhold dronedarone if treatment is essential, with ECG monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Dronedarone
- Adagrasib + Dronedarone Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Azithromycin + Dronedarone Contraindicada
- Chloroquine + Dronedarone Contraindicada
Perguntas frequentes
Can I take Artemether / lumefantrine with Dronedarone?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both components prolong the QT interval, and the combination with dronedarone increases torsades risk. Artemether is also a CYP3A4 substrate with possible effects on dronedarone exposure, though QT additivity is the main concern.
How serious is the interaction between Artemether / lumefantrine and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antimalarial without QT liability or withhold dronedarone if treatment is essential, with ECG monitoring.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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