Drug interactions
Artemether / lumefantrine + Dronedarone
Severity: Contraindicated
Artemether / lumefantrine and Dronedarone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both components prolong the QT interval, and the combination with dronedarone increases torsades risk. Artemether is also a CYP3A4 substrate with possible effects on dronedarone exposure, though QT additivity is the main concern.
What this interaction means in plain words
Artemether / lumefantrine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation, with possible CYP3A4-mediated pharmacokinetic effects.
What to do
Avoid the combination; use an antimalarial without QT liability or withhold dronedarone if treatment is essential, with ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Chloroquine + Dronedarone Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Dronedarone?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both components prolong the QT interval, and the combination with dronedarone increases torsades risk. Artemether is also a CYP3A4 substrate with possible effects on dronedarone exposure, though QT additivity is the main concern.
How serious is the interaction between Artemether / lumefantrine and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antimalarial without QT liability or withhold dronedarone if treatment is essential, with ECG monitoring.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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