Interações medicamentosas
Artemether / lumefantrine + Phenytoin
Gravidade: Contraindicada
Artemether / lumefantrine and Phenytoin: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Phenytoin is a strong inducer of CYP3A4 and can markedly lower artemether and lumefantrine concentrations. This may lead to treatment failure of malaria and promote recrudescence or resistance.
O que esta interação significa em palavras simples
Artemether / lumefantrine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Induction of CYP3A4-mediated metabolism of artemether and lumefantrine by phenytoin.
O que fazer
Avoid the combination and choose an antimalarial or anticonvulsant that is not a strong enzyme inducer. If unavoidable, seek specialist advice and monitor parasitological response closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenytoin
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
- Ensitrelvir + Phenytoin Contraindicada
Perguntas frequentes
Can I take Artemether / lumefantrine with Phenytoin?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is a strong inducer of CYP3A4 and can markedly lower artemether and lumefantrine concentrations. This may lead to treatment failure of malaria and promote recrudescence or resistance.
How serious is the interaction between Artemether / lumefantrine and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antimalarial or anticonvulsant that is not a strong enzyme inducer. If unavoidable, seek specialist advice and monitor parasitological response closely.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Bictegravir, Cabotegravir, Doravirine. The full list is on the Phenytoin page.
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