Interações medicamentosas
Doravirine + Phenytoin
Gravidade: Contraindicada
Doravirine and Phenytoin: contraindicated interaction.
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Resumo
Phenytoin markedly lowers doravirine concentrations, which may result in loss of virologic response and NNRTI resistance.
O que esta interação significa em palavras simples
Doravirine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
Por que acontece
Phenytoin induces CYP3A4, which is the main metabolic pathway of doravirine.
O que fazer
Do not co-administer; use a non-inducing anticonvulsant. Doravirine labeling also advises against starting it soon after inducer discontinuation until induction wanes.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
- Ensitrelvir + Phenytoin Contraindicada
Outras interações de Doravirine
- Amobarbital + Doravirine Contraindicada
- Apalutamide + Doravirine Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Doravirine + Efavirenz Contraindicada
- Doravirine + Enzalutamide Contraindicada
- Doravirine + Mitotane Contraindicada
Perguntas frequentes
Can I take Doravirine with Phenytoin?
MediHelp rates the interaction as contraindicated. Doravirine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin markedly lowers doravirine concentrations, which may result in loss of virologic response and NNRTI resistance.
How serious is the interaction between Doravirine and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing anticonvulsant. Doravirine labeling also advises against starting it soon after inducer discontinuation until induction wanes.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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