Interações medicamentosas
Artesunate + Imatinib
Gravidade: Moderada
Artesunate and Imatinib: moderate interaction.
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Resumo
Imatinib may inhibit UGT-mediated glucuronidation of dihydroartemisinin, the active metabolite of artesunate, and raise its exposure. This could increase adverse effects such as hematologic toxicity.
O que esta interação significa em palavras simples
Artesunate and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Imatinib belongs to Oncology.
Por que acontece
Inhibition of UGT enzymes by imatinib reduces clearance of dihydroartemisinin.
O que fazer
Monitor for increased adverse effects and check blood counts if treatment is prolonged; no routine dose change is established.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Imatinib
- Imatinib + Lomitapide Contraindicada
- Imatinib + Lonafarnib Contraindicada
- Amobarbital + Imatinib Grave
- Apalutamide + Imatinib Grave
- Avapritinib + Imatinib Grave
- Benzhydrocodone / acetaminophen + Imatinib Grave
Outras interações de Artesunate
- Artesunate + Rifampicin Grave
- Artesunate + Carbamazepine Moderada
- Artesunate + Eltrombopag Moderada
- Artesunate + Nevirapine Moderada
- Artesunate + Phenytoin Moderada
- Artesunate + Regorafenib Moderada
Perguntas frequentes
Can I take Artesunate with Imatinib?
MediHelp rates the interaction as moderate. Artesunate and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may inhibit UGT-mediated glucuronidation of dihydroartemisinin, the active metabolite of artesunate, and raise its exposure. This could increase adverse effects such as hematologic toxicity.
How serious is the interaction between Artesunate and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects and check blood counts if treatment is prolonged; no routine dose change is established.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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