Interações medicamentosas
Avapritinib + Imatinib
Gravidade: Grave
Avapritinib and Imatinib: major interaction.
Última atualização
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Resumo
Avapritinib is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor. Avapritinib exposure may increase, raising risks of cognitive effects, intracranial hemorrhage and edema. Both are kinase inhibitors, and imatinib is also used in GIST, where combination is not typical.
O que esta interação significa em palavras simples
Avapritinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Imatinib belongs to Oncology.
Por que acontece
CYP3A4 inhibition by imatinib reduces avapritinib clearance.
O que fazer
Avoid the combination if possible. If necessary, use the reduced avapritinib starting dose from labeling and monitor for cognitive effects and bleeding.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Imatinib
- Imatinib + Lomitapide Contraindicada
- Imatinib + Lonafarnib Contraindicada
- Amobarbital + Imatinib Grave
- Apalutamide + Imatinib Grave
- Benzhydrocodone / acetaminophen + Imatinib Grave
- Bosutinib + Imatinib Grave
Outras interações de Avapritinib
Perguntas frequentes
Can I take Avapritinib with Imatinib?
MediHelp rates the interaction as major. Avapritinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor. Avapritinib exposure may increase, raising risks of cognitive effects, intracranial hemorrhage and edema. Both are kinase inhibitors, and imatinib is also used in GIST, where combination is not typical.
How serious is the interaction between Avapritinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, use the reduced avapritinib starting dose from labeling and monitor for cognitive effects and bleeding.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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