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Interações medicamentosas

Articaine + Nadolol

Gravidade: Moderada

Articaine and Nadolol: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Articaine is formulated with epinephrine, and unopposed alpha stimulation in a patient on a nonselective beta-blocker can cause hypertension with reflex bradycardia. The effect is usually transient but can be significant.

O que esta interação significa em palavras simples

Articaine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Articaine belongs to Central Nervous System; Nadolol belongs to Cardiovascular.

Nível de evidência: Moderate

Por que acontece

Nonselective beta-blockade leaves epinephrine's alpha-mediated vasoconstriction unopposed.

O que fazer

Do not stop nadolol before dental anesthesia; use the minimum epinephrine-containing dose with aspiration and monitor blood pressure and heart rate.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Articaine with Nadolol?

MediHelp rates the interaction as moderate. Articaine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Articaine is formulated with epinephrine, and unopposed alpha stimulation in a patient on a nonselective beta-blocker can cause hypertension with reflex bradycardia. The effect is usually transient but can be significant.

How serious is the interaction between Articaine and Nadolol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop nadolol before dental anesthesia; use the minimum epinephrine-containing dose with aspiration and monitor blood pressure and heart rate.

What other medicines interact with Nadolol?

MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.

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