Interações medicamentosas
Articaine + Timolol
Gravidade: Moderada
Articaine and Timolol: moderate interaction.
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Resumo
Dental articaine is usually given with epinephrine. In patients on nonselective beta-blockers, unopposed alpha stimulation by epinephrine can cause hypertension with reflex bradycardia.
O que esta interação significa em palavras simples
Articaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Articaine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Por que acontece
Timolol blocks beta-2 mediated vasodilation, leaving epinephrine's alpha-mediated vasoconstriction unopposed.
O que fazer
Do not stop the beta-blocker before the procedure. Use the minimum effective epinephrine dose with aspiration to avoid intravascular injection, and monitor blood pressure and heart rate.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Timolol
- Acebutolol + Timolol Grave
- Albuterol + Timolol Grave
- Aldesleukin + Timolol Grave
- Amifostine + Timolol Grave
- Amiodarone + Timolol Grave
- Arformoterol + Timolol Grave
Outras interações de Articaine
- Articaine + Nadolol Moderada
- Articaine + Propranolol Moderada
Perguntas frequentes
Can I take Articaine with Timolol?
MediHelp rates the interaction as moderate. Articaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dental articaine is usually given with epinephrine. In patients on nonselective beta-blockers, unopposed alpha stimulation by epinephrine can cause hypertension with reflex bradycardia.
How serious is the interaction between Articaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop the beta-blocker before the procedure. Use the minimum effective epinephrine dose with aspiration to avoid intravascular injection, and monitor blood pressure and heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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