Interações medicamentosas
Atazanavir + Darifenacin
Gravidade: Grave
Atazanavir and Darifenacin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Atazanavir is a strong CYP3A4 inhibitor and can substantially raise darifenacin exposure. This increases the risk of anticholinergic effects such as dry mouth, constipation, urinary retention and QT-related concerns at high concentrations.
O que esta interação significa em palavras simples
Atazanavir and Darifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Darifenacin belongs to Genitourinary.
Por que acontece
Inhibition of CYP3A4-mediated metabolism of darifenacin.
O que fazer
Limit darifenacin to 7.5 mg daily with strong CYP3A4 inhibitors and monitor for anticholinergic adverse effects, or choose an alternative.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Darifenacin
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Darifenacin?
MediHelp rates the interaction as major. Atazanavir and Darifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can substantially raise darifenacin exposure. This increases the risk of anticholinergic effects such as dry mouth, constipation, urinary retention and QT-related concerns at high concentrations.
How serious is the interaction between Atazanavir and Darifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit darifenacin to 7.5 mg daily with strong CYP3A4 inhibitors and monitor for anticholinergic adverse effects, or choose an alternative.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Bethanechol, Clarithromycin, Clozapine. The full list is on the Darifenacin page.
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